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P3‐289: Apolipoprotein E and phosphodiesterase 4D variants associated with cognitive decline in elderly African‐Americans
Author(s) -
Murrell Jill,
Lane Katie,
Xuei Xiaoling,
Flury L.,
Foroud Tatiana,
Edenberg Howard,
Unverzagt Fred,
Hendrie Hugh,
Gao Su,
Hall Kathleen
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1857
Subject(s) - cognitive decline , single nucleotide polymorphism , apolipoprotein e , snp , bonferroni correction , cognition , medicine , effects of sleep deprivation on cognitive performance , dementia , gerontology , demography , genotype , genetics , biology , psychiatry , gene , disease , statistics , mathematics , sociology
Background: The brain is the most cholesterol-rich organ in the human body. The metabolic syndrome, a clustering of several commonly disorders that include hyperlipidemia, may be a risk factor for memory decline in the elderly. Apolipoprotein E (Apo E) is a lipoprotein that transports cholesterol and other lipids. The Cyp46 enzyme is a member of the cytochrome P450 family of proteins. It regulates the elimination of excess cholesterol by adding a hydroxyl group to cholesterol. Previous studies have shown that high serum total cholesterol level is a risk factor for dementia, and may be as well as the clinical hallmark for progressive memory impairment. The aim of this study was to clarify the role of lipid-related gene (APOE, CYP46) in memory performance in middle-aged and elderly adults without dementia. Methods: Using cross-section design, 209 cognitively intact participants were recruited. The mean age (SD) was 67.87 (6.80) years, the mean duration of education was 11.07 (3.91) years, and 49.76% were women. Memory and learning function were measured by logical memory (I) (II), world list (I) (II) and spatial span of the Wechsler Memory Scale-III (WMS-III). Serum levels of total cholesterol, triglyceride, HDL/LDL cholesterol, and gene polymorphisms (APOE and CYP46) were analyzed. Results: After adjustment for age, gender, education and socioeconomic status, participants with moderate high cholesterol levels (200-239mg/dL) performed well in learning ability (p 0.0092). There was no significant association between those with and without APOE 4 genotype on Memory performance. On the contrast, CYP46 gene polymorphisms was significantly associated with logical memory performance (p 0.0006). Conclusions: The CYP46 gene polymorphisms may play an important role in episodic memory performance and SNP4-AA genotype may be a risk factor for memory impairment. The moderate high total cholesterol level, however, is positively associated with learning performance. Finally, Cholesterol level, APOE and CYP46 gene polymorphisms have no interaction effect on memory performance.