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P3‐240: Genome‐wide analysis of gene‐gene interaction in Alzheimer's disease
Author(s) -
Martin Eden R.,
Turner Stephen D.,
Beecham Gary W.,
Gilbert Johnny R.,
Haines Jonathan L.,
Pericak-Vance Margaret A.,
Ritchie Marylyn D.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1807
Subject(s) - multifactor dimensionality reduction , genome wide association study , apolipoprotein e , single nucleotide polymorphism , locus (genetics) , genetics , genetic association , biology , gene , computational biology , disease , genotype , medicine
We performed Chi-squared analysis, logistic regression analysis, HardyWeinberg Equilibrium, Kaplan-Meier survival-analysis method and Cox proportional Hazard analyses and Cox regression model. After the follow up period the patients were separated into three groups: 27 subjects who remained the MCI diagnosis, 40 that converted to AD before 20 months and 22 that converted to AD after. To assess the risk associated to each genotype a control group without cognitive impairment was included (n 90). Results: APOE4 allele was associated with an increased risk of developing a MCI (OR: 6.04, 95% CI: 2.76-3.23; p 0.001) but did not have an effect on the probability of evolving AD. ACT polymorphism was not associated with MCI but appear to modify the risk of progression to dementia increasing the risk to develop an AD before 20 months (HR 2.03; 95% CI: 1-4.6; p 0.06). ACT genotype increases the risk of quick evolution to dementia higher than age or years of schooling by Cox regression. Conclusions: We conclude that APOE is a risk gene for developing amnestic MCI and ACT gene modify the time of progression to AD in MCI patients.