Premium
P3‐209: Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease
Author(s) -
Carson Robyn,
Craig David,
Hart Dominic,
Johnston Janet A.,
O'Neill Francis A.,
Passmore A. Peter
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1776
Subject(s) - psychosis , linkage disequilibrium , haplotype , single nucleotide polymorphism , executive dysfunction , nicotinic acetylcholine receptor , genetic association , nicotinic agonist , psychology , genetics , allele , psychiatry , medicine , genotype , biology , cognition , neuropsychology , receptor , gene
PLINK gave an adjusted p-value of 1.3x10 for the chisq test. Rs5984894 maps to a 102-kb LD block on Xq21.3 that is entirely within the gene encoding protocadherin 11, X-linked (PCDH11X). The PCDH11X gene is a member of the protocadherin subfamily of calcium-dependent cell adhesion and recognition proteins, which are particularly prevalent in the central nervous system. Conclusions: Our two-stage LOAD GWAS shows genome-wide significance for rs5984894, a variant that maps to a 102-kb LD block entirely within PCDH11X. These results warrant further examination of PCDH11X as a LOAD susceptibility gene.