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IC‐P3‐229: Assessment of global cortical atrophy and medial temporal lobe atrophy in suspected and definite dementia: Comparison of magnetic resonance imaging and 64 multi‐detector row computed tomography
Author(s) -
Wattjes Mike P.,
Vrenken Hugo,
Flier Wiesje M.,
Geurts Jeroen J.J.G.,
Gillissen Freek,
Romkes Rolinka,
Scheltens Philip,
Barkhof Frederik
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.174
Subject(s) - magnetic resonance imaging , coronal plane , dementia , medicine , atrophy , gold standard (test) , temporal lobe , cohen's kappa , radiology , nuclear medicine , neuroimaging , cerebral atrophy , kappa , pathology , epilepsy , psychiatry , computer science , disease , machine learning , linguistics , philosophy
Results: Full-course swimming time was obviously longer in model group than these in treated and control group. In model group, the expression of PSD-95 and synaptophysin decreased, expression of -Synuclein increased. Treated group normalized the expression of the targeted proteins. Retrograde degeneration of neuron of hippocampus was observed In model group, and dysmorphic synapses were observed In the neuropil. Conclusions: There were low PSD-95, synaptophysin levels and high -Synuclein levels in the brain of ICV injection of STZ rats. Analog 165 of APP5-mer peptide improves the expression of the three proteins to some extent; therefore it may protect synapse and improve learning ability and memory.