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P3‐171: Redefining “normal” cognitive performance in ageing using Aβ neuroimaging
Author(s) -
Pike Kerryn E.,
Villemagne Victor L.,
Ellis Kathryn A.,
Jones Gareth,
Ackermann Uwe,
O'Keefe Graeme,
Ames David,
Masters Colin L.,
Rowe Christopher C.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1737
Subject(s) - pittsburgh compound b , neuropsychology , cognition , dementia , neuropsychological assessment , medicine , neuroimaging , psychology , audiology , disease , psychiatry
tests aimed at assessing basic cognitive functions and awareness of modern life: short interview (autobiographical memory, knowledge of presentday), verbal ability (fluency tests, word comprehension, sorting test: concept formation/visual memory (naming), abstract thinking), spatial capacity (length estimation, drawing), arithmetic and episodic memory. Administration time is about 20 minutes. The goal is to recruit 50 healthy persons matched by age (45-80 years) and level of education, 25 MCI patients, 25 AD patients and 10 FTD patients. A follow-up will be performed on all patients on two occasions after one and two years. Results: A pre-study has been carried through with three healthy controls and two patients. One of the patients had MCI and the other FTD. The result of the pre-study is shown in the figure. For each cognitive domain the maximum point is 100 and the minimum is 0. Conclusions: Although there are few participants in the pre-study, there are, as expected, obvious differences between the patients and the healthy controls. This is a promising attempt, but the instrument needs further development regarding reliability, validity, relevance, utility, normal variation and cut-off values.