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P3‐143: A comparison study in the cognitive functions between the Alzheimer's disease and the Alzheimer's disease with cerebrovascular disease: Korean case study
Author(s) -
Jeong Dushin,
Kim Tae-Woong,
Oh Hyung-Geun,
Joung Jae-Hoon,
Park Hyung-Kook,
Yang Youngsoon,
Song In-Uk
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1708
Subject(s) - dementia , disease , neuropsychology , cognitive decline , medicine , neuropsychological test , alzheimer's disease , cognition , vascular dementia , stroke (engine) , clinical dementia rating , psychiatry , mechanical engineering , engineering
Background: Recent advances in the epidemiology of Alzheimer disease suggest strong association between vascular factors predisposing to cerebrovascular disease and Alzheimer disease (AD). Furthermore, recent study reported that subjects with episodes of cerebrovascular disease had a greater risk of developing dementia than those without stroke. We achieve this study to compare cognitive decline between two groups of patients with Alzheimer disease without and with cerebrovascular disease on neuropsychological test. Methods: Of seventy patients with AD diagnosed by available clinical and radiological assessment, 66 patients had pure AD, and 64 patients had AD with cerebrovascular disease (ADV). These patients received neuropsychological test, including the Korea version of Mini-Mental State Examination, the expended version of Korean Clinical Dementia Scale (CDR), and Global Deterioration Scale (GDS). Results: The mean K-MMSE, CDR, sum of box of CDR, GDS of pure AD were 20.8 3.99, 0.85 0.57, 4.30 2.92, 3.80 0.71, respectively. Those of ADV were 17.1 5.06, 1.28 0.74, 7.17 5.10, 4.23 0.77. There were no differences in age, sex, education, and duration of AD between groups. All score of neuropsychological test in ADV showed more severe cognitive decline than those in pure AD. Conclusions: In this study, cognitive function of ADV patients is more severe decline than AD patients, indicating that cerebrovascular disease contribute to the severity of cognitive decline in AD patients. These results suggest that intensive prevention of cerebrovascular disease plays an important role in prevention of rapid cognitive decline in patients with AD.