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P3‐097: Prediction of progressive mild cognitive impairment using cerebrospinal fluid biomarkers: Results from the Gothenburg mild cognitive impairment study
Author(s) -
Svensson Maria,
Nordlund Arto,
Jonsson Michael,
Eckerström Carl,
Lind Karin,
Rolstad Sindre,
Syversen Steinar,
Pedersen Mona,
Mattsson Ulla-Britt,
Zetterberg Henrik,
Andreasson Ulf,
Edman Åke,
Blennow Kaj,
Wallin Anders
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1661
Subject(s) - dementia , cerebrospinal fluid , cognitive impairment , medicine , lumbar puncture , disease , etiology , oncology , cognitive decline , cognition , biomarker , pathology , psychiatry , biochemistry , chemistry
%, specificity of 75.7 % and an OR of 9.5 (p 0.001). Furthermore low A 42 levels were associated with inability to live in regular housing and a worse mini mental status examination (MMSE) score (p 0.05), whereas the individuals developing pathological memQoL were slower in cognitive speed (p 0.01) compared to those cognitively stable. Conclusions: The AD-associated combination of low CSF A 42 and high CSF P-tau predicted subjective cognitive decline over 3 year in healthy elderly. Our results suggest that AD-related pathological changes in the brain might be detectable already in a clinically normal elderly population.