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P3‐046: Predicting dementia using instrumental activities of daily living in the development of screening guidelines and diagnostic criteria for predementia Alzheimer's disease study
Author(s) -
Sikkes Sietske A.M.,
Pijnenburg Yolande A.L.,
Lange de Klerk Elly S.M.,
Visser Pieter Jelle,
Knol Dirk L.,
Verhey Frans,
Uitdehaag Bernard M.J.,
Scheltens Philip
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1609
Subject(s) - activities of daily living , dementia , gerontology , logistic regression , psychology , alzheimer's disease , medicine , disease , psychiatry
parts of evaluation for dementia. Objectives: To examine the presence of presumed correlations between CDTs, general cognitive scores, and Instrumental Activities of Daily Living (IADL) scale in cognitively impaired patients. Methods: We reviewed the charts of the 123 patients with complaining the memory impairments; 42 Dementia of the Alzheimer’s type, 38 vascular dementia, and 43 mild cognitive impairments. The patients had all undergone the Mini-Mental State Examination (MMSE), Hasegawa Dementia Scale (HDS), Clinical Dementia Rating (CDR) to determine the severity of dementia, and IADL for assessment of functional disabilities. The CDT was scored by 3 different scoring methods; modified Shulman, quantitative scoring system by Rouleau et al, and Cahn methods reflecting qualitative analyses. Results: The patients were 78 women and 45 men; their mean age was 69.93 years ( 9.34) (range 44 86). The mean MMSE , HDS, and IADL scores were 19.85 6.03, 16.89 6.90, and 0.83 0.90, respectively. The mean CDT scores by each scoring method were Shulmnan 3.53 1.61, Rouleau 5.66 3.11, and Cahn 2.03 3.33. CDR and IADL was significantly correlated with all methods of scoring the CDT. In specific error types, there were more qualitative errors in patients with worse functional impairments (IADL score 0.43; 1.24 0.72 ) than those with less functional impairments (IADL score 0.43; 0.74 0.84 ) (p 0.01). All correlations between CDT scoring methods were statistically significant (r 0.940-0.983, p 0.01). Conclusions: Deterioration in CDT score correlates with severity of global cognitive impairment, as assessed by the MMSE, HDS, CDR, and also correlates with IADL. Therefore we could predict that dementing patients who exhibited a significantly greater decline on the CDT is more likely to have functional disabilities.