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P3‐036: The impact of memory test scores and neuroimaging on the clinical diagnosis of Alzheimer's dementia
Author(s) -
Oksengard Anne Rita H.,
Axelsson Rimma,
Cavallin Lena,
Andresson Christin,
Nägga Katarina,
Jönhagen Maria E.,
Wahlund Lars-Olof
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1599
Subject(s) - dementia , pathological , memory clinic , cerebral blood flow , medicine , neuroimaging , atrophy , cognitive impairment , memory impairment , episodic memory , disease , cognition , psychology , audiology , psychiatry
Patients and controls were matched for age (66.3 4.3 and 67.2 6.8 years, p 0.57), education (7.1 4.9 and 8.7 4.1 years of schooling; p 0.24), and cognitive state (all non-demented). Subjects were yearly assessed with the CAMCOG, a brief but comprehensive cognitive battery comprising orientation, language, memory, attention, praxis, gnosis, calculation and abstraction sub-scores. Patients were euthymic at the time of cognitive evaluation (HAMD-21 7 and YMRS 4). Results: Baseline CAMCOG scores for patients and controls were respectively 90.5 7.8 and 93.1 6.0 (p 0.20). After one year of follow-up, the total CAMCOG scores were 90.3 7.6 and 93.9 8.0 (p 0.12), and after two years 90.9 8.0 and 95.0 6.8 (p 0.065) respectively. Conclusions: No significant differences on cognitive outcome were found between patients with and without bipolar disorder, even though there was a trend of increasing difference of the cognitive outcome between the two groups. Larger samples and longer follow-up periods may be necessary to detect incident deficits. The existence of unrecognized cognitive disturbances in these patients may have important implications in the adherence to medication and other therapeutic interventions, and the early identification of such dysfunctions may result beneficial to the global outcome.