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P3‐019: Diverse neurological symptoms presenting severe dementia, psychiatric Symptoms and motor deficits in early‐onset familial Alzheimer's disease
Author(s) -
Ikeda Masaki,
Yonemura Kimie,
Yoshida Jun'ichi,
Fujita Yukio,
Hashimoto Yukiko,
Ishiguro Koichi,
Oriuchi Noboru,
Harigaya Yasuo,
Okamoto Koichi
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1582
Subject(s) - apathy , proband , dementia , atrophy , medicine , disease , parkinsonism , anosognosia , psychology , pathology , neuroscience , mutation , genetics , gene , biology
brain imaging was performed in 3 cases of CBS-AD and 7 cases of CBS-CBD. All cases of CBS-AD demonstrated decreased activity in the parietal lobes, and all CBS-CBD cases showed decreased activity in the temporal or frontal lobes. Conclusions: Alzheimer disease like CBD can present as clinical CBS. Clinical features and structural imaging are insufficient to distinguish between the two pathologic substrates. However, age at onset after 65, the presence of tremor and decreased frontotemporal activity on functional imaging are more suggestive of CBD as underlying pathology for clinical CBS.