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P3‐012: Immunochemical analysis of advanced glycation endproducts and amyloid in Alzheimer's disease and diabetic post‐mortem brain tissue
Author(s) -
Gella Alejandro,
Valente Tony,
Unzeta Mercedes,
Fernandez-Busquets Xavier,
Durany Nuria
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1575
Subject(s) - senile plaques , pathology , pathogenesis , thioflavin , microglia , glycation , medicine , alzheimer's disease , amyloid (mycology) , immunohistochemistry , hippocampus , amyloid beta , diabetes mellitus , disease , endocrinology , inflammation
nificantly smaller in groups taking angiotensin II type-2 receptor blockers (ARBs) or brain -penetrating ACE-Is than in groups taking non-brain penetrating ACE-I or calcium channel blockers. Conclusions: We concluded that the use of ARBs and brain-penetrating ACE-Is could be beneficial to manage AD patients with hypertension to slow the progression of dementia. Therefore physicians should be more careful in choosing antihypertensive drug for AD patients with hypertension.