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P2‐481: Small molecule BACE‐1 inhibitors are potent, selective and orally active
Author(s) -
Malamas Michael,
Erdei Jim,
Gunawan Iwan,
Robichaud Albert,
Turner Jim,
Hu Yun,
Wagner Erik,
Aschmies Suzan,
Comery Tom,
Fan Kristi,
Chopra Rajiv,
Magolda Ron,
Pangalos Menelas,
Reinhart Peter,
Riddell David,
Jacobsen Steve,
Abou-Gharbia Magid,
Bard Jonathan
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1559
Subject(s) - amyloid precursor protein , peptide , chemistry , proteases , ic50 , amyloid precursor protein secretase , ligand (biochemistry) , cleavage (geology) , p3 peptide , biochemistry , small molecule , active site , binding site , alzheimer's disease , enzyme , pharmacology , in vitro , biology , receptor , medicine , disease , paleontology , fracture (geology)