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IC‐P3‐210: White matter hyperintensities are related to cognitive and motor function in middle‐aged healthy individuals
Author(s) -
Sachdev Perminder,
Wen Wei,
Parslow Ruth,
Anstey Kaarin
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.154
Subject(s) - hyperintensity , cognition , psychology , physical medicine and rehabilitation , memory span , audiology , working memory , physical therapy , medicine , magnetic resonance imaging , neuroscience , radiology
2005. At study entry, participants underwent a multidimensional assessment evaluating cognitive, functional and psychobehavioral domains. Every concomitant illness and treatment was recorded. Patients were grouped in categories (patients with low, medium and high albumin levels). Results: The total sample of patients showed a cognitive improvement from baseline of the ADAS Cog score at three months (ADAS Cog mean change -1,4 5,4; p 0,01), a cognitive stabilization at nine (ADAS Cog mean change 0,03 6,7; p NS) and a worsening not statistically significant at fifteen months (ADAS Cog mean change 0,9 7,3; p NS). The study demonstrates that lower serum albumin levels are associated with a greater response of donepezil. In fact, cognition, evaluated with ADAS Cog mean change from baseline, improved during the first 15 months of treatment in lower serum albumin level group, while worsened in higher serum albumin level groups. Conclusions: Data suggest the importance of taking in consideration various clinical and biological parameters to predict the clinical efficacy of ChEIs therapy.