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P2‐455: The neurocognitive effects of donepezil on visual short‐term memory capacity following 24 Hours of sleep deprivation
Author(s) -
Pan Martin,
Chuah Lisa Y.M.,
Chen Annette,
Chong Delise,
Rekshan William,
Tan Jiat-Chow,
Lai Robert Y.K.,
Libri Vincenzo,
Chee Michael W.L.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1534
Subject(s) - psychology , audiology , sleep deprivation , visual cortex , placebo , donepezil , neurocognitive , working memory , neuroscience , medicine , dementia , cognition , disease , alternative medicine , pathology
on the basis of high confidence hits and misses while low confidence hits and non-responses were modeled as a single predictor. Results: EpM performance (A’), was significantly impaired by SD. Donepezil improved A’ during SD to a greater extent in subjects who were more severely impaired by SD. Donepezil led to a larger increase in left inferior prefrontal activation compared to placebo during SD conditions, which was positevely correlated with donepezil benefit on A’. The left prefrontal region showing this effect was the same as that associated with a subsequent memory effect. Conclusions: Donepezil was associated with greater improvement of verbal EpM in volunteers who showed greater decline in this domain when SD. The locus of this benefit appears to be dependent on the task suggesting that improvements in attention may be the mechanism through which cognitive benefit is realized.