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P2‐386: Physical activity and enhanced fitness improve cognitive function in older people without known cognitive impairment: A Cochrane systematic review
Author(s) -
Angevaren Maaike,
Aufdemkampe Geert,
Verhaar Harald J.J.,
Aleman Andre,
Vanhees Luc
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1464
Subject(s) - cardiorespiratory fitness , aerobic exercise , cinahl , cognition , randomized controlled trial , physical fitness , psycinfo , physical therapy , physical medicine and rehabilitation , medicine , psychological intervention , psychology , medline , gerontology , psychiatry , political science , law
sTNF-RI levels and increases dissociable-free IGF-I values, it is concluded that this compound seems to diminish the hyperactivity of peripheral TNF-alpha system and to enhance IGF-I bioavailability. These effects of Cere might contribute to reduce inflammatory and pro-apoptotic activities of TNF-alpha and to stimulate neurotrophic and anti-amyiloidogenic actions of serum IGF-I in AD, which could be relevant for the influence of Cere on the disease progression.