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IC‐P3‐201: A new dynamic imaging method of neuronal abnormalities and differential diagnosis
Author(s) -
Musha Toshimitsu,
Matsuzaki Haruyasu,
Takao Takeo
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.145
Subject(s) - abnormality , scalp , cerebral blood flow , premovement neuronal activity , hypoactivity , electroencephalography , medicine , cardiology , neuroscience , nuclear medicine , psychology , anatomy , psychiatry
pocampus. Apo e4 carrier state was known in 11 AD (ApoE3/ApoE4: 3/8) and 38 controls (ApoE3/ApoE4: 29/14). Entorhinal cortex (ERC), subiculum, CA1, CA1-CA2 transition zone (CA1-2 transition), CA3-4& dentate gyrus (CA3&DG) and total hippocampal volume were manually marked. Statistical analysis was done with multiple regression and stepwise discriminant analysis. Results: Compared to controls, AD had significantly smaller volumes of ERC (-28.4%), subiculum (-23.0%), CA1 (-20.2%), CA1-2 transition (-31.4%) and total hippocampal volumes (-19.1%). MCI had smaller CA1 (-14%) and CA1-2 transition (-26.1%) volumes. CA1-2 transition discriminated best between controls and MCI (Wilks’ Lambda 0.68, p 0.0001) and CA1-2 transition and ERC (Wilks’ Lambda 0.63, p 0.0001) between AD and control. ApoE4 exerted a negative effect on CA3&DG volumes in healthy controls (p 0.036) and in a mixed group of AD and controls (p 0.0003). In the latter group we also found a significant interaction between AD and ApoE4 (p 0.029). Conclusions: The patterns of subfield atrophy in AD and MCI were consistent with patterns of neuronal cell loss/ reduced synaptic density described in histopathologcal studies. ApoE4 effects were restricted to CA3&DG, i.e., the subfield capable of neurogenesis throughout adult life. These preliminary findings suggest that hippocampal subfield volumetry might be a better measure for diagnosis of early AD and for detection of other disease effects than measurement of total hippocampal volume.