Premium
IC‐P3‐197: Apolipoprotein genotype predicts rate of brain atrophy in healthy elderly adults: A tensor‐based morphometry study
Author(s) -
Lu Po-Haong,
Thompson Paul,
Leow Alex,
Lee Grace,
Lee Agatha,
Geschwind Daniel,
Stewart Stephanie,
Bartzokis George
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.141
Subject(s) - atrophy , apolipoprotein e , brain size , white matter , genotype , allele , medicine , temporal lobe , pathology , psychology , cardiology , magnetic resonance imaging , neuroscience , biology , disease , genetics , epilepsy , radiology , gene
delineated regions. Results: Absolute volumes from FreeSurfer differed from manual volumes to different extents depending on region and subject group but were largely due to differences in protocols with more temporal stem white matter included in FreeSurfer regions. Volume differences (FreeSurfer-manual) were different between controls and SD (p 0.05), but not between control-AD or between AD-SD groups. Importantly however, expressed as fraction of control volume the FreeSurfer results showed a very similar pattern of loss to that found with manual measures (Table). In the SD group the most severely atrophied regions were the left entorhinal cortex, left amygdala and left parahippocampal gyrus. Furthermore, greatest atrophy in the AD group was shown bilaterally in the entorhinal cortex and hippocampus. There was no evidence for left-right asymmetry in the control or AD groups. In the SD group the left temporal volumes were significantly smaller than the equivalent right-sided structures (p 0.0001) (Figure). Conclusions: Despite absolute volumes differing for FreeSurfer and manual segmentations, between-group comparisons revealed remarkably similar patterns of loss with the two methods: in AD symmetrical losses were most marked in the entorhinal cortex and hippocampus whereas SD showed profound asymmetrical, predominantly left-sided, atrophy affecting in particular the anterior and medial temporal lobe structures. IC-P3-196 CLINICAL EVALUATION OF F-LABELED AV138 FOR PET AMYLOID IMAGING IN ALZHEIMER’S DISEASE