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P2‐315: A novel biotherapy for the treatment of Alzheimer's disease
Author(s) -
Yu Jin,
Gattoni-Celli Sebastiano,
Zhu Hong,
Kindy Mark S.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1392
Subject(s) - senile plaques , immunology , biology , cancer research , medicine , alzheimer's disease , disease
factor receptor (EGFR). This process was mediated through metallo-complex modulation of integrin metabolism resulting in src-kinase stimulation and potent cognate-ligand independent activation of EGFR. This resulted in downstream activation of ERK and up-regulation of amyloid beta peptide-degrading matrix metalloprotease activity. Metallo-complexes induced a significant reduction in the level of extracellular amyloid beta peptide 1-40 and 1-42 in cell cultures through this mechanism. Conclusions: These findings provide the first evidence that metal-ligand complexes can activate EGFR with potentially neuroprotective effects for treatment of Alzheimers disease.