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IC‐P3‐179: Quantifying metabolic asymmetry in Alzheimer's disease using both MR and PET imaging
Author(s) -
Fletcher P. Thomas,
Wang Angela Y.,
Foster Norman L.,
Joshi Sarang C.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.123
Subject(s) - asymmetry , brain asymmetry , positron emission tomography , neuroimaging , medicine , lateralization of brain function , nuclear medicine , psychology , physics , neuroscience , quantum mechanics
been modeled previously and include pool-specific T1 and T2 values (T1,F, T1,S, T2,F, T2,S) and volume fractions (fF, fS) as free parameters, allowing their estimation from multi-flip angle SPGR and SSFP data. For in vivo demonstration, whole-brain data were acquired of 4 healthy volunteers on a 1.5T Siemens Sonata clinical scanner. Imaging parameters were: 22cm2 16cm field of view, 256x160x118 matrix, SPGR: TE/TR 3.1ms/6.5ms, angles 2° through 18° in 2° increments; SSFP: TE/TR 2.3ms/4.6ms, angles 6° though 70° in 8° increments. Results: Images through the T1,F, T1,S, T2,F, T2,S and myelin fraction maps are shown in Fig. 1. Mean values obtained from different brain regions are shown in Fig. 2 and agree well with previous literature reports.