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P2‐115: Influence of vascular risk factors on cognitive performance in community‐dwelling African Americans
Author(s) -
Khosropour Christine M.,
Dowling N. Maritza,
Wharton Whitney,
Edwards Dorothy F.,
Carlsson Cynthia M.,
Asthana Sanjay,
Gleason Carey E.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1189
Subject(s) - stroop effect , cognition , verbal fluency test , gerontology , medicine , cognitive decline , clinical psychology , trail making test , geriatric depression scale , demography , psychology , neuropsychology , psychiatry , dementia , depressive symptoms , disease , sociology
systolic and diastolic blood pressure with autopsy findings controlling for gender, age at death, and the time between blood pressure measurement and death. Results: Brain autopsies were performed on 250 subjects, 107 of whom (43%) were male, with mean (SD) age at death of 86.1 (6.8). Mean (SD) time between enrollment and death was 7.2 (3.0) years. Each 10 mmHg increase in SBP at enrollment was associated with 15% increased risk of microinfarcts (relative risk [RR] 1.11, 95% confidence interval [CI] 1.01-1.22), 6% increase in risk for atherosclerosis (RR 1.06, 95% CI 1.01-1.10), and no increase in risk for macroscopic infarction (RR 1.02, 95% CI 0.94-1.11). Each 5 mmHg increase in DBP was not associated with increased risk of microinfarcts (RR 0.97, 95% CI 0.79-1.20), 7% increase in risk for atherosclerosis (RR 1.07, 95% CI 1.00-1.13), and no increase in risk for macroscopic infarction (RR 1.00, 95% CI 0.87-1.14). Conclusions: These results confirm the association of elevated SBP and DBP with increased risk for atherosclerosis, and suggest that elevated SBP (but not DBP) is also associated with increased risk for microinfarcts. Further investigation of the significance of this finding is warranted.