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P2‐112: Is a low percent calories from saturated fat reported at midlife related to the presence of late‐life dementia among survivors?
Author(s) -
Goldbourt Uri,
Schnaider-Beeri Michal
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1186
Subject(s) - calorie , medicine , quartile , dementia , polyunsaturated fat , saturated fat , gerontology , socioeconomic status , demography , snacking , cohort , logistic regression , disease , environmental health , obesity , population , confidence interval , cholesterol , sociology
had diabetes. Of 51 PD subjects, 25.49% had nl cognitive function, 7.8% had MCI, 33.4% moderate (vs. 36.4% in HD), and 33.4% severe CI (37% in HD). No subject had a pre-existing documented diagnosis of CI. On univariate and logistic regression analyses including common risk factors for CI, only diabetes was associated with severe cognitive impairment in the PD cohort; OR 1.59 (1.06, 2.36). When all three HD, PD, and nonCKD cohorts were combined in the model, PD was associated with an increased risk of severe CI compared to nonCKD patients (OR 2.653 (1.018, 6.915) as was HD; OR 3.752 (1.990, 7.072). Conclusions: Moderate to severe CI is almost as common in PD patients as HD patients. Although stroke was associated with severe CI in HD pts in previous analyses, only diabetes was associated with severe CI in PD patients. However, our power was limited by the small PD sample size, and our results may not be generalizable to other PD populations. Nevertheless, given that 2/3 of the PD cohort had moderate to severe CI, patients undergoing peritoneal dialysis would benefit from cognitive assessment prior to and periodically after dialysis initiation.