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P2‐109: Lifetime cigarette smoking is protective toward Lewy body pathology
Author(s) -
Tsuang Debby,
Li Gail,
Shofer Jane,
Larson Eric,
Leverenz James,
Montine Thomas
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1183
Subject(s) - prospective cohort study , cohort , medicine , autopsy , lewy body , cohort study , substantia nigra , pathology , parkinson's disease , psychology , disease
tioning (AEF) and visuospatial functioning. There are no published analyses on this issue in cognitively normal (CN) subjects in any populationbased sample. We want to test the hypothesis that CN subjects who have probable RBD (pRBD) will have lower AEF and visuospatial functioning compared to CN subjects without pRBD. Methods: Participants are 70-89 year old residents of Olmsted County, Minnesota. The neuropsychological battery assessed performance in the AEF, memory, language, and visuospatial domains. A domain score was computed and transformed to a z-scale to allow comparisons. pRBD was considered present based on the Mayo Sleep Questionnaire-a validated screening measure for RBD. Data were analyzed for subjects who underwent the key assessments and were considered CN. Results: Among 765 subjects, the frequency of pRBD was 8.0%. Those with pRBD had significantly lower median scores (25-75 percentile scores) for the AEF domain (0.08 [-0.56, 0.58] vs. 0.37 [-0.21, 0.85] in subjects without pRBD; p 0.01). Scores were also lower in subjects with pRBD vs. those without pRBD across the other domains memory (0.08 [-0.31, 0.70] vs. 0.21 [-0.40, 0.83], p 0.55); language (0.14 [-0.46, 0.53] vs. 0.30 [-0.28, 0.85], p 0.10); and visuospatial (0.31 [-0.42, 0.94] vs. 0.40 [-0.22, 0.94], p 0.42), although none reached statistical significance. Subjects with lower AEF scores were more likely to have pRBD (OR 1.31, 95% CI 0.91, 1.87, p 0.15) after adjustment for age and education (as continuous variables) and sex, but the CI included 1. Conclusions: Among CN subjects, probable RBD is associated with lower scores on AEF. Whether LBD is the most common etiology for this association will require further study.