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P2‐104: Rapid T2‐mapping of brain atrophy using a Talairach atlas correlates with neuropsychometric measures in classifying normal aging, mild cognitive impairment and stages of Alzheimer's disease
Author(s) -
Zimmerman Earl A.,
Henderson David L.,
Staples Natalie A.,
Gillen Robert,
Cowan John M.,
Schenck John
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1178
Subject(s) - parahippocampal gyrus , atrophy , voxel , dementia , audiology , medicine , psychology , clinical dementia rating , neuroscience , pathology , temporal lobe , disease , radiology , epilepsy
with lower levels of hippocampal neuronal metabolism as measured by MRS neurochemistry, but not hippocampal volume. Furthermore, decreased stride length is associated with smaller hippocampal volumes, but not hippocampal neurochemistry. If confirmed in larger samples, this pattern of results suggests that distinct neurobiological substrates may support decreased stride length and increased variability in older adults. Additional investigation is necessary to examine the longitudinal sequence of motor, cognitive, neurochemical and neuroanatomic changes in normal aging and dementia.