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P2‐103: MRI‐ and MRS‐derived hippocampal correlates of quantitative gait dysfunction in older adults
Author(s) -
Zimmerman Molly E.,
Lipton Richard B.,
Pan Jullie W.,
Hetherington Hoby P.,
Verghese Joe
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1177
Subject(s) - neurochemistry , gait , stride , neurology , physical medicine and rehabilitation , psychology , magnetic resonance imaging , hippocampal formation , intraclass correlation , dementia , neuroscience , medicine , psychometrics , developmental psychology , disease , radiology
patients with delusion and their age-sex-severity matched probable AD patients without delusion were underwent fluorodeoxy-glucose positron emission tomography (FDG-PET) scanning. Paranoid delusion was defined using Korean version of Behavior Rating Scale for Dementia (Youn et al., 2008). The mean differences in the regional cerebral glucose metabolism between paranoid and non-paranoid groups were estimated based on the results of voxel-by-voxel comparison using statistical parametric mapping (SPM2) and partial least square (PLS, McIntosh and Lobaugh, 2004). To identify the functional connectivity, seed-voxel PLS analysis was performed. Results: Neuropsychiatric symptoms other than paranoid delusion were not significantly different between AD patients with and without delusion. Paranoid delusion ( ) group had significantly decreased cerebral glucose metabolism in temporal area including left hippocampus (BA36, ,y,z -32,-24,-6), right parahippocampal gyrus (BA36, ,y,z 20,-40,12) and right inferior frontal gyrus (BA 47, ,y,z 58,38,-8) than paranoid delusion (-) group (p 0.05, uncorrected for SPM, p 0.01 for PLS). Seed-voxel PLS analysis using peak metabolic rates in the hippocampus and inferior frontal gyrus as seeds identified four different connectivity patterns (LV1-4). Paranoid delusion ( ) group was significantly correlated with LV 1 and LV 4, whereas paranoid delusion (-) group was significantly correlated with LV 2 and LV 3 (p 0.001). Conclusions: This study showed that altered functional connectivity of frontal and temporal lobe was important for the development of paranoid delusion in AD.