P2‐095: Working memory activation in mild cognitive impairment and older adults with cognitive complaints

non-verbal fluid type intelligence (Raven’s Standard Progressive Matrices test [RPM]). From this sample, 52 individuals (aged 69/70) with an age 11 IQ between 85 and 115 and who had a RPM of 34 (group mean 0.5 SD), representing those who had cognitive decline (decliners, n 27) or a score of 41 (group mean 0.5 SD) representing successful ageing (sustainers, n 25) were recruited into this functional MRI study. Working memory was assessed with a two-condition N-Back task. Fifteen participants failed to complete the task because of an inability to correct vision, feeling unwell or scoring below 50% correct for the 2-Back task. Results: In a comparison of the high load working memory task (2-Back) with rest, extensive differences in activation were found in the cognitive decliners compared with the sustainers in the frontal, parietal and cerebellar regions. Conclusions: These data add to the evidence that prefrontal cortical regions are important in maintaining working memory as people age. Parietal and cerebellar regions are also involved in working memory; however their importance in successful cognitive ageing is unclear.