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P2‐065: Volume loss and parahippocampal white matter integrity in amnestic mild cognitive impairment
Author(s) -
Rogalski Emily J.,
Murphy Chris M.,
Toledo-Morrell Leyla,
Shah Raj C.,
Trivedi Mehul A.,
Wang Chengsheng,
Stebbins Glen T.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1138
Subject(s) - white matter , diffusion mri , parahippocampal gyrus , magnetic resonance imaging , entorhinal cortex , temporal lobe , hippocampus , region of interest , neuroscience , nuclear medicine , psychology , medicine , radiology , epilepsy
hypothesized that aMCI patients would show attenuated functional connectivity in medial parietal and temporal cortex compared to age-matched controls. We also hypothesized that functional connectivity in midline cortical regions important for self-appraisal would inversely correlate with level of anosognosia. Methods: Sixteen MCI patients and sixteen age and education control participants were included in the analysis. The vPCC region showing activity to self-appraisal in a sample of 203 cognitively healthy adults was used as the seed region for the analysis; correlation maps were generated guided by published procedures. Results: Our analysis of group differences in functional connectivity revealed that MCI participants show attenuated connectivity in the PCC and a ventromedial prefrontal region (Figure 1). We also examined the relationship between functional connectivity and level of cognitive anosognosia in the MCI group. Results revealed a significant inverse relationship between level of cognitive anosognosia and functional connectivity in the ventromedial prefrontal cortex and bilateral hippocampi (Figure 2). Conclusions: This finding highlights the level of anosognosia in MCI as an important predictor of functional connectivity in brain regions important for self-appraisal that are vulnerable to changes associated with early AD.