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P2‐037: Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's disease neuroimaging initiative
Author(s) -
Lee Wendy,
Langbaum Jessica B.S.,
Chen Kewei,
Recshke Cole,
Bandy Daniel,
Alexander Gene E.,
Foster Norman L.,
Weiner Michael W.,
Koeppe Robert A.,
Jagust William J.,
Reiman Eric M.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1118
Subject(s) - statistical parametric mapping , positron emission tomography , posterior cingulate , precuneus , dementia , neuroimaging , medicine , superior frontal gyrus , voxel , clinical dementia rating , alzheimer's disease , parahippocampal gyrus , nuclear medicine , alzheimer's disease neuroimaging initiative , fluorodeoxyglucose , psychology , cardiology , magnetic resonance imaging , cortex (anatomy) , neuroscience , radiology , temporal lobe , disease , cognition , epilepsy
genetic risk factor of Alzheimer’s disease (AD). Recent histopatholgical and MRI studies in patients with AD demonstrated alterations of white matter, as well as gray matter. This study aimed to investigate possible associations between cerebral white matter changes and APOE genotype in early stage AD. Methods: The authors used Diffusion Tensor Imaging (DTI) to explore cerebral white matter changes to detect pathological processes. 26 AD participants were included in the study of which 13 were APOE 4 carriers and age-, gender-, and severity-matched 13 were APOE 4 non-carriers. All AD individuals were met for NINCDS-ADRDA Diagnostic Criteria of probable AD and their global scores of Clinical Dementia Rating scale were 0.5 or 1. Voxel-based comparisons for the Fractional Anisotropy (FA) and Mean Diffusivity (MD) were performed between APOE 4 carriers and 4 non-carriers using SPM5. Results: FA value was significantly lower in APOE 4 carriers than APOE 4 non-carriers in the bilateral temporal white matter, right cingulate white matter, left parahippocampal white matter, right postcentral parietal white matter, bilateral frontal and occipital white matter. Compared to APOE 4 non-carriers, APOE 4 carriers had significant increase of the MD value in the bilateral medial frontal white matter, right inferior frontal white matter, left precentral white matter, and left posterior cingulate white matter (p 0.005, uncorrected for multiple comparisons). Conclusions: Although the exact mechanism underlying vulnerability of white matter tracts in APOE 4 carriers is still unclear, these findings indicate that increased genetic risk by APOE 4 allele is associated with advanced regional alterations of white matter, as well as gray matter changes, in early stage AD.