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P2‐028: Rate of whole brain volume decline in a cohort of cognitively normal participants with family history of Alzheimer's disease: A longitudinal study
Author(s) -
Kastman Erik K.,
Bendlin Barbara B.,
Xu Guofan,
Ries Michele L.,
McLaren Donald G.,
Fitzgerald Michele E.,
Jabbar Britta M.,
Kosmatka Kristopher J.,
Johnson Sterling C.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1109
Subject(s) - cohort , dementia , cognitive decline , medicine , family history , brain size , neuropsychology , cohort study , gerontology , disease , cognition , demography , psychology , magnetic resonance imaging , psychiatry , sociology , radiology
ments were obtained. An ANCOVA was performed for each of the NP tests and SNI variables, using group membership as fixed factors, and age, sex and years of education as covariates. Only variables with a significant group effect in the ANCOVA (13 NP tests and 33 SNI variables) were used. A canonical correlation analysis was then performed between those NP and SNI variables. Results: We found that the first five of the canonical-variate-pairs (CVP) were statistically significant. The contribution of each of the NP and SNI variables to the canonical correlation depended on the canonical-dimension of each CVP, as follows. The first CVP related to language and attention with bilateral involvement of SNI; the second CVP had a stronger relation to language with elements of memory and attention, and involved mostly left hemispheric SNI; the third CVP related to more global deficits and bilateral SNI contribution; the fourth CVP related mostly to memory with bilateral SNI involvement; finally, the fifth CVP related mostly to attention with left hemispheric SNI involvement. Conclusions: These results reveal how information in the SNI relates to specific aspects of cognitive deficit.