Premium
P2‐026: Interrelation between cortical nicotinic receptors and acetylcholinesterase activity in mild Alzheimer's patients as assessed by PET
Author(s) -
Kadir Ahmadul,
Almkvist Ove,
Wall Anders,
Långström Bengt,
Nordberg Agneta
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1106
Subject(s) - acetylcholinesterase , cholinergic , nicotinic agonist , nicotine , medicine , psychology , neuroscience , positron emission tomography , acetylcholine , cognition , endocrinology , receptor , chemistry , biochemistry , enzyme
generated from the VOIs using a MATLAB code. Parametric images of amyloid retention were generated by averaging the images (approximately 50-70 min postinjection) from a subset of subjects and normalizing that to the cerebellum grey to get a standardized uptake value ratio (SUVR). Data across the subset of subjects was compared using the statistical methods of SPM. Results: The VOI analysis showed increased uptake of 18F-tracers in cortical grey matter areas expected to contain -amyloid plaques associated with Alzheimer’s disease (AD) for all three tracers. The statistical analysis on the voxel specific parametric images showed significant uptake (p 0.05) in orbito-frontal and lateral temporal cortices as well as precuneus and posterior cingulate. Thus SPM statistical analysis supports the semiautomated VOIs quantification methods. These results are consistent with reported findings of amyloid pathology in AD in postmortem tissue. SPM analysis for the full set of data is underway and will be presented. Conclusions: Semiautomated approach provides a precise method for quantifying the uptake of 18F-labelled imaging agents for imaging -amyloid plaque in multicenter trials.