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P2‐006: Baseline data from a multi‐centre, prospective longitudinal study of ageing in 1000 volunteers (the AIBL study)
Author(s) -
Ellis Kathryn A.,
Rowe Christopher C.,
Masters Colin L.,
Martins Ralph N.,
Hudson Peter,
Milner Andrew,
Bevege Lindsay,
Savage Greg,
Ames David
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1086
Subject(s) - cohort , medicine , population , prospective cohort study , dementia , neuropsychology , clinical dementia rating , psychology , gerontology , disease , cognition , psychiatry , environmental health
mann syndromes, visual agnosia and transcortical motor aphasia. We report a large series of PCA with a SPECT exam aimed at defining the specificity of the perfusion profile of PCA. Objectives: 1) To define the brain perfusion profile of PCA; 2) to compare the whole brain perfusion profile between PCA and that of typical Alzheimer’s disease (AD) and 3) to study the relationships between cognitive deficits and cerebral perfusion. Methods: Sixty-three subjects were included: 18 PCA patients; 18 AD patients (matched by the mean disease duration and by the MMSE score) and 27 age matched normal controls. Each patient underwent a neuropsychological evaluation and a SPECT (99mTc-ECD). The SPECT images were analyzed on the voxel scale with the SPM2 software (p 0,05). Results: When compared to the AD group, the hypoperfusion in PCA patients was more extensive and severe especially in the visual associative cortex (precuneus, BA 18/19) and in the parietal associative cortex (BA 39/40). When compared to the control group, the perfusion profile of PCA group was characterized by: 1) a bilateral and symmetrical hypoperfusion in parieto-temporo-occipital cortex, with a maximal decrease in the associative parietal cortex (superior parietal lobule) and in the precuneus; 2) a bilateral and symmetrical hypoperfusion in dorsolateral frontal lobes from BA 6/8 (Frontal Eyes Field) to BA 9. 3). The perfusion analyze within the PCA group showed: 1) a more severe hypoperfusion in the right parieto-temporo-occipital cortex in the subgroup of patients with neglect (n 10) than in the patients without neglect (n 8); 2) a more severe hypoperfusion in the right associative occipital cortex in the patients with visual apraxia (n 7) than in the patients without visual apraxia (n 11). Conclusions: The SPECT is a valuable tool for PCA because it can help for distinguishing it from AD and for understanding the neurological foundations of the symptoms.