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P1‐475: High potent Aβ1–42 oligomers involved in toxicity of BV2 microglial cells and primary microglia
Author(s) -
Selenica Maj-Linda B.,
Pedersen Lars
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1058
Subject(s) - microglia , viability assay , neuroinflammation , mtt assay , toxicity , potency , neurotoxicity , ec50 , chemistry , acute toxicity , biochemistry , in vitro , pharmacology , cell , microbiology and biotechnology , biology , immunology , inflammation , organic chemistry
phy and characterized utilizing Western blots and mass spectrometry. Results: A 40 and A 42 monomeric and oligomeric forms are associated to cortical plasma membranes and raft microdomains of the cerebral cortex of AD and ND control individuals. Conclusions: Plasma membrane bound A demonstrated important physicochemical alterations between AD and ND control individuals. These differences may in part explain the neuropathological features and clinical manifestations observed in AD.