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P1‐461: The role of cholesterol level alterations upon APP and BACE proximity and APP cleavage
Author(s) -
Arnim Christine A.F.,
Einem Björn,
Schwanzar Daniel,
Weber Petra,
Wagner Michael,
Schneckenburger Herbert
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1044
Subject(s) - förster resonance energy transfer , cleavage (geology) , endosome , chemistry , biophysics , total internal reflection fluorescence microscope , cell membrane , secretion , cell , microbiology and biotechnology , membrane , cholesterol , amyloid precursor protein , fluorescence microscope , lipid raft , membrane fluidity , lipid bilayer , fluorescence , biochemistry , alzheimer's disease , materials science , biology , medicine , physics , disease , quantum mechanics , fracture (geology) , composite material
tion, *P 0.001 vs. Control). The MMP inhibitors did not have direct antioxidant effects. Treatment of animals with the antioxidant PBN or MMP inhibitor minocycline did not have a significant effect on CAA progression rates measured with longitudinal imaging when compared to untreated mice (untreated 0.51%, PBN 0.51, minocycline 0.54 % vessel segment affected per week). Conclusions: These data offer insights on the molecular pathways activated by vascular amyloid and suggest a close association between A -related MMP activation and ROS generation in vivo. They also raise the possibility that therapeutic treatment with MMP inhibitors may have beneficial effects in the A amyloidosis by indirectly reducing the oxidative stress associated with CAA Acknowledgements: NIH EB000768, AG020570, AG024688, AG021084, Harvard Neurodiscovery Center (R.A.B.), Leffler fellowship (CP), Bugher Foundation fellowship (M.G-A).