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IC‐P2‐104: Entorhinal atrophy is related to increased hippocampal fMRI activation during encoding in mild cognitive impairment
Author(s) -
Jauhiainen Anne M.,
Pihlajamäki Maija,
Tervo Susanna,
Niskanen Eini,
Hänninen Tuomo,
Tanila Heikki,
Vanninen Ritva L.,
Soininen Hilkka
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.097
Subject(s) - entorhinal cortex , hippocampal formation , hippocampus , temporal lobe , neuroscience , atrophy , psychology , episodic memory , recognition memory , audiology , cognition , medicine , epilepsy
imaging studies. The scarcity of NFT labeling with 6-CN-PiB, as well as the very low binding in brain regions with heavy NFT density, suggests strongly that the presence of NFT does not contribute to PiB retention levels in vivo. Furthermore, the novel observation that 6-CN-PiB can label eNFT, which are known to contain aggregated A , suggests that PiB binding to these lesions is likely driven by the presence of A fibrils rather than the amyloid structure of tau.