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IC‐P2‐083: Effects of actual and simulated Z‐shifts on freesurfer‐segmented whole‐brain tissue, hippocampal, and lateral‐ventricle volumes
Author(s) -
Caramanos Zografos,
Fonov Vladimir,
Derakhshan Mishkin,
Collins D. Louis,
Narayanan Sridar,
Arnold Douglas L.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.076
Subject(s) - scanner , isocenter , voxel , nuclear medicine , imaging phantom , biomedical engineering , ventricle , coordinate system , materials science , physics , computer science , medicine , optics , computer vision , cardiology
on magnetic resonance imaging (MRI) with Osiris method was compared between the study (n 26; AD) and control (n 24; healthy volunteers) groups. Topographic measurements included the cross sectional area of entire CC, width of genu, middle part (body), and posterior (splenium) from a midsagittal MRI slice. Results: Mean age of the patients with AD and the controls were 68.9 10.6 vs 67.4 13.1 years respectively. Mini Mental State Examination (MMSE) score were comparable to the volunteers in the patients with AD [18.9 4.4 to 29.2 0.7; p 0.05]. The width of splenium, CC body, rostral portion of the genu and the total CC area were significantly lower in the AD patients than the volunteers [0.9 0.1 cm; 0.4 0.1 cm; 0.8 0.2 cm; and 4.7 0.9 cm2 vs 1.2 0.2 cm; 0.6 0.1 cm; 1.1 0.3 cm; and 5.6 0.6 cm2, respectively; (p 0.001)]. Also, significant positive correlation between MMSE scores and CC measurements were observed in AD patients (r p 0.001). Negative correlation between CC area and disease duration was not statistically significant. The serum Low Density Lipoprotein (LDL) levels were significantly higher in AD patients than in control group [124,08 28,57 vs 114,92 23,72 respectively; (p0.05). Conclusions: The results of this study suggest that callosal atrophy in AD may suggest the severity of the disease. Osiris method for CC measurements may be used as an easy and reliable method used to asses the severity of disease.