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IC‐P1‐047: Near‐infrared fluorescence imaging in transgenic mouse models of Alzheimer's disease
Author(s) -
Raymond Scott B.,
Ferrara Brian G.,
Kumar Anand T.N.,
Boas David A.,
Bacskai Brian J.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.057
Subject(s) - fluorophore , molecular imaging , fluorescence , fluorescence lifetime imaging microscopy , amyloid (mycology) , genetically modified mouse , amyloid beta , transgene , neuroimaging , chemistry , pathology , biophysics , biomedical engineering , in vivo , medicine , neuroscience , biology , biochemistry , optics , disease , physics , microbiology and biotechnology , gene
strongest correlations with parietal and medial temporal A burden in MCI (both r -.56, p .001) and superior frontal A burden in HCs (r -.25, p .02). Conclusions: The relationship between cognition and PiB uptake is not regionally specific. The strong relationship between episodic memory impairment (the earliest cognitive change in AD) and PiB uptake in nondemented individuals supports the notion that PiBPET can detect AD prior to development of dementia.