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IC‐P1‐040: Brain atrophy: A risk factor for cognitive decline only when white matter lesions are present? The SMART‐MR study
Author(s) -
Muller Majon,
Appelman Auke P.A.,
Graaf Yolanda,
Mali Willem P. Th M.,
Geerlings Mirjam I.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.051
Subject(s) - atrophy , hyperintensity , cardiology , cognitive decline , medicine , white matter , psychology , brain size , pathology , dementia , magnetic resonance imaging , disease , radiology
old Ts65Dn. Ts65Dn mice had higher CBV values than controls, again in the subiculum and CA3. In 67% of the hippocampal slices isolated from the same Ts65Dn mice, spontaneous interictal-like activity discharges were recorded in the CA3 subregion. In contrast epileptiform activity was virtually absent in slices from control mice. A high correlation (r 0.88) between the number of slices with epileptiform bursts and CBV values in CA3 was observed. Conclusions: Based on these findings, we propose that in AD mouse models, there is a very early detectable phase (present work), with a subsequent phase of cell dysfunction and thirdly, a well-documented later phase of neuronal loss. Since Ts65Dn mice develop some aspects of AD pathology after 6 months, these results are consistent with the aforementioned hypothesis. Also, the data indicate that the hypersynchronous activity developed in the CA3 of young Ts65Dn mice is associated with the hypermetabolic state. These findings support the view that, in AD, we can identify a time point in which early/preventive treatment may be used and monitored.