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IC‐03‐06: Six month MRI gray matter declines in Alzheimer's dementia evaluated by voxel‐based morphometry with multivariate network analysis: Preliminary findings from the ADNI study
Author(s) -
Alexander Gene E.,
Hanson Krista D.,
Chen Kewei,
Reiman Eric M.,
Bernstein Matthew A.,
Kornak John,
Schuff Norbert W.,
Fox Nick C.,
Thompson Paul M.,
Weiner Michael W.,
Jack Clifford R.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.011
Subject(s) - statistical parametric mapping , voxel , temporal lobe , multivariate statistics , neuroimaging , dementia , magnetic resonance imaging , atrophy , voxel based morphometry , multivariate analysis , white matter , gray (unit) , nuclear medicine , psychology , alzheimer's disease , medicine , neuroscience , disease , radiology , mathematics , statistics , epilepsy
with previous studies emphasizing relationships between frontal mediated cognitive task performance and WMH (Table 3). Greater increase in WMH volume was also significantly associated with greater declines in MMSE and multiple measures of executive function (Table 4). Conclusions: ADNI subjects possess MRI evidence of CVD that increases with time and is significantly associated with decline in frontally mediated cognitive function. These findings suggest that CVD may additionally influence the trajectory of cognitive change accompanying neurodegeneration, even in this select cohort of very healthy subjects. Moreover, the effect of CVD should be taken into account when evaluating the viability of AD markers obtained from this cohort as well treatment effects in clinical trials for which these data are being modeled.