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Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementia
Author(s) -
Griffith H. Randall,
Hollander Jan A.,
Okonkwo Ozioma C.,
O'Brien Timothy,
Watts Ray L.,
Marson Daniel C.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.04.008
Subject(s) - creatine , dementia , choline , posterior cingulate , medicine , glutamate receptor , alzheimer's disease , endocrinology , disease , gastroenterology , psychiatry , cognition , receptor
Background Few comparative studies exist of metabolic brain changes among neurodegenerative illnesses. We compared brain metabolic abnormalities in Alzheimer's disease (AD) and in Parkinson's disease with dementia (PDD) as measured by proton magnetic resonance spectroscopy (MRS). Methods Twelve patients with idiopathic PDD, 22 patients with probable mild AD, and 61 healthy older controls underwent posterior cingulate MRS. Results Patients with AD exhibited reduced N‐acetyl aspartate (NAA)/creatine (Cr) ( P < .05) and increased choline (Cho)/Cr ( P < .05) and myo ‐inositol (mI)/Cr ( P < .01) compared with controls. Patients with PDD exhibited reduced NAA/Cr ( P < .05) and glutamate (Glu)/Cr ( P < .01) compared with controls. There was reduced Glu/Cr in PDD compared with AD ( P < .01). Conclusions Patients with AD and patients with PDD exhibited distinct brain metabolic MRS profiles. Findings suggest that comparison of brain MRS profiles across dementias provides useful direction for future study.