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Genetics and dementia: Risk factors, diagnosis, and management
Author(s) -
Hsiung GingYuek Robin,
Dessa Sadovnick A.
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.07.010
Subject(s) - dementia , frontotemporal dementia , disease , medicine , genetic counseling , clinical practice , genetic testing , molecular genetics , psychiatry , psychology , genetics , family medicine , pathology , biology , gene
New developments in molecular genetics have improved our understanding on a number of neurodegenerative dementias considerably, especially Alzheimer's disease and frontotemporal dementia. However, this explosion of information can be overwhelming to clinicians, making it difficult to integrate into regular clinical practice. In this article, we briefly reviewed our current understanding regarding causative genetic mutations and genetic risk factors on the major forms of dementia, which provided the background information for discussion in the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia. The principles of genetic counselling were applied. Guidelines and recommendations on the application of genetics in the assessment, diagnosis, and management of patients and families with dementia were summarized.