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O1–01–04: Midlife proficiency with written Japanese and late life dementia risk among Japanese‐American men. The Honolulu‐Asia aging study
Author(s) -
Crane Paul,
Gibbons Laura E.,
Arani Keerthi,
Nguyen Viet Q.,
Rhoads Kristoffer,
McCurry Susan,
Launer Lenore,
Masaki Kamal,
White Lon
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.358
Subject(s) - dementia , gerontology , vascular dementia , medicine , logistic regression , proportional hazards model , demography , longitudinal study , psychology , disease , pathology , sociology
was to investigate the possible effect modification of the apoE e4 allele for several lifestyle related risk factors for dementia and AD. Methods: Participants of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study were derived from random, population-based samples previously studied in 1972, 1977, 1982, or 1987. After an average follow-up of 21 years, 1449 (73%) aged 65 to 79 years were reexamined in 1998. Results: The apoE e4 allele was an independent risk factor for dementia even after adjustments for lifestyle and vascular factors (OR 2.83, 95% CI 1.61-4.97). Physical inactivity, alcohol drinking, and smoking at midlife increased the risk of dementia and AD particularly among the apoE e4 carriers. Further, among the apoE e4 carriers low to moderate dietary intake of polyunsaturated fats at midlife, as well as moderate to high intake of saturated fats were associated with increased risk of dementia and AD. Also the summarized effect of the lifestyle related factors was more pronounced among the apoE e4 carriers. Conclusions: Physical inactivity, dietary fat intake, alcohol drinking, and smoking at midlife are associated with the risk of dementia and AD, especially among the apoE e4 carriers. The apoE e4 carriers may be more vulnerable for various lifestyle related factors. Thus, especially the carriers of the apoE e4 allele might benefit from adopting a healthy and moderate lifestyle.