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P‐064: Measurement of β‐amyloid isoforms in human plasma using the INNO‐BIA plasma Aβ forms:(Pre)‐clinical validation
Author(s) -
Vanderstichele Hugo M.,
Demeyer Leen,
Vandecasteele Lies,
Decraemer Hilde,
Van Remoortere Sandy,
Catry Cindy,
De Meyer Geert,
Kostanjevecki Vesna,
Vanmechelen Eugeen
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.317
Subject(s) - biological fluids , human plasma , chemistry , chromatography , computational biology , biology
(p 0 0001), whereas, after adjustment for age and sex, episodic memory and executive function did not. Baseline hippocampal atrophy was associated with increasing atrophy rates (hippocampal volume: p 0 025; MTA-score: p 0 008), in contrast whole brain volume, WMH and lacunes, adjusted for age and sex, were not significantly associated with hippocampal atrophy rates. Conclusions: In MCI, older age, poorer general cognition, hippocampal atrophy and APOE e4 predict subsequent accelerated rates of hippocampal atrophy, suggestive of the accumulation of Alzheimer-type pathology, which may become clinically manifest in the future. These markers may improve identification of MCI subjects at risk for AD.