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P‐054: Decreased posterior cingulate bold response in healthy middle‐aged adults with a parental history of Alzheimer's disease
Author(s) -
Ries Michele L.,
Fitzgerald Michele E.,
Jabbar Britta,
Gliori Gemma,
Sager Mark,
Asthana Sanjay,
Johnson Sterling
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.307
Subject(s) - precuneus , posterior cingulate , family history , psychology , episodic memory , disease , neuroscience , alzheimer's disease , cognition , audiology , medicine
ment of amyloid deposits (1.5mo), A 42 can readily be drawn into the plasma, but not after the transition to amyloid deposition, demonstrating that amyloid deposition efficiently sequesters A 42 disallowing access to the blood. The experimental approach described in the present study could provide a method to determine when a given individual has begun to deposit amyloid in the brain and is thus at higher risk for developing AD.