Premium
P‐052: Changes in brain ventricle volume associated with mild cognitive impairment and Alzheimer disease in subjects participating in the Alzheimer's disease neuroimaging initiative (ADNI)
Author(s) -
Nestor Sean M.,
Rupsingh Raul,
Accomazzi Vittorio,
Borrie Michael,
Smith Matthew,
Wells J.,
Bartha Robert
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.305
Subject(s) - ventricle , atrophy , cardiology , brain size , medicine , neuroimaging , magnetic resonance imaging , third ventricle , cognitive impairment , cognitive decline , dementia , disease , psychology , radiology , psychiatry
in the group as a whole and in the control group alone. Results: In the total population, CA1, but none of the other subfields, positively correlated with GM in the inferior and lateral temporal lobe and posterior and midline thalamic nuclei. Controls showed additional correlations in the posterior and mid cingulate but smaller correlations in the thalamus. In addition, CA1 was highly correlated with perfusion in the lateral temporal lobes and the orbito-frontal fronto-opercular regions and posterior and anterior cingulate in the total population. (cf. Figure 1a and b). Conclusion: The brain regions showing positive structural and functional correlations with CA1 volume in this study are consistent with the known projections of CA1 (Gloor P, 1997) and thus provide in vivo validation of our method for subfield quantification. Taken together these results suggest that measurement of hippocampal subfields is a valid and sensitive approach to investigation of normal aging and early AD.