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P‐049: Lower baseline weight and faster weight loss predict time to develop dement ia in the nun study
Author(s) -
Mortimer James A.,
Snowdon David A.,
Wu Yougui,
Markesbery William R.
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.265
Subject(s) - weight loss , medicine , dementia , weight change , proportional hazards model , hazard ratio , weight gain , demography , gerontology , obesity , body weight , confidence interval , disease , sociology
known as DTIStudio, followed by manual identification of regions of interest (ROIs) by skilled operators, using a standardized protocol with previously established reliability. Results: The ROIs included: 1) fornix, 2) splenium, 3) cerebral peduncles, and 4) cingulum. Measures of fractional anisotropy (FA) within each ROI were analyzed with linear mixed effects models and intraclass correlation. Two ROIs showed cross-sectional differences between the groups: the fornix (p 0.009, and the splenium (p 0.009). Over the first 3 month follow-up interval, during which the participants were clinically stable, there were no significant changes in mean FA within any of the ROIs, as assessed by linear mixed effects analysis. Intraclass correlations of the mean FA value within the ROIs showed moderate-to-strong stability. Conclusions: These findings suggest that DTI measures may be useful as indicators of clinical status in AD. Additional data are needed over longer follow-up intervals in order to more fully assess their utility as surrogate markers in clinical trials.