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P‐004: Incorporating ethnicity into genetic risk assessment for Alzheimer's disease: The reveal study experience
Author(s) -
Christensen Kurt D.,
Roberts J. Scott,
Royal Charmaine D.M.,
Fasaye Grace-Ann,
Obisesan Thomas,
Cupples L. Adrienne,
Whitehouse Peter J.,
Butson Melissa B.,
Linnenbringer Erin,
Relkin Norman R.,
Farrer Lindsay,
Green Robert C.
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.220
Subject(s) - ethnic group , disease , risk assessment , gerontology , randomized controlled trial , medicine , psychology , genetic testing , demography , pathology , sociology , computer security , anthropology , computer science
patients [average age 72 (range 61-90, SD 6), average education 11 years (range 4-20 years, SD 2.7)] who were randomly recruited from Grady Health Systems Medical clinics. Subjects were given the Folstein Mini Mental State Exam, Draw a Clock task, four item Memory Impairment Screen and Time and Change Task. Results: 186 patients were able to complete the MMSE, with an average completion time of 6.6 minutes (range 2.7-19.3 SD 2.5). The higher the z score, indicating better performance, the less time it took to complete the MMSE (r -.50, p .001). Impaired patients took significantly longer (mean 480.2 seconds, SE 19.8) than intact patients (mean 345.2 seconds, SE 10.5). Using norms from Crum et al., 63 patients (33.9%) scored in the impaired range. Thirty-six patients took longer than eight minutes to complete the MMSE. Of these, 24 (67%) scored impaired, and 12 (33%) scored non-impaired. Of the 12 non-impaired patients, four additional patients were impaired on the Clock Drawing Test, indicating that 78% of patients who took longer than eight minutes were impaired on one of the two screens. Conclusion: Results suggest that an eight minute time limit on the MMSE may be effective in identifying African Americans with mild cognitive impairment or other forms of dementia who are in need of more detailed evaluation and treatment.