P‐110: Withdrawn

been shown to lower PTH. Age-induced enhanced PTH plasma levels are associated with prolonged P300 latency and cognition decline. P300 latency is a better predictor of preclinical dementia than memory or mental status tests. We determined if PTH levels correlate to brain speed and/or bone density. In this study, patients (n 92, age-matched, age 12-90 years, mean 58.85, SD 15.47) had PTH levels tested compared to brain speed (P300). The study groups were: PTH levels 30 (n 30, mean 22.7 5.6 SD) and PTH levels 30 (n 62, mean 62.4 28.3 SD, p .02). Groups were compared for age, bone density and P300 latency. One-tailed tests were used to ascertain the statistical significance of the correlations. Patients with PTH levels 30 showed statistically significantly less P300 latency (P300 332.7 4.8 SE) relative to those with high PTH levels 30, which demonstrated greater P300 latency (P300 345.7 3.6 SE, p .02). Participants with PTH values 30 (n 26) were found to have statistically significantly higher bone density (M -1.25 .31 SE) than those with PTH values 30 (n 48, M -1.85 .19 SE, p .04). In order to test the hypothesis of reduced PTH levels following a pulsed administration of PTH, like calcium and vitamin D, we found a significant difference between pre and post injection PTH levels, Pre-PTH injection n 12, M 43.67, SD 25.35, post-PTH injection n 12, M 23.30, SD 20.31, P . 01). Our findings of a statistically lower bone density and prolonged P300 in patients with high PTH levels may suggest that PTH levels coupled with delayed P300 latency may become putative biological markers of not only dementia but OP. Additionally, PTH injection may be a useful treatment in lowering PTH levels. This study provides the first potential indirect evidence that may highlight the importance of brain processing speed as an OP early electrophysiological marker, which warrants intensive investigation.