Premium
P‐191: Dietary DHA ameliorates amyloid‐β and tau pathology via a mechanism involving presenilin 1 levels
Author(s) -
Green Kim,
Martinez-Coria Hilda,
Hall Eileen,
Yurko-Mauro Karin,
Ellis Lorie,
LaFerla Frank
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.154
Subject(s) - docosahexaenoic acid , docosapentaenoic acid , presenilin , polyunsaturated fatty acid , western diet , arachidonic acid , endocrinology , medicine , chemistry , biochemistry , disease , fatty acid , biology , alzheimer's disease , enzyme , obesity
A 42-induced caspase 3/7 activity. The effect of tramiprosate on A -induced caspase 3/7 activation was significantly reduced by pretreating the cells with specific GABAAR antagonists. Conclusions: These results demonstrate that tramiprosate behaves as a functional agonist for the GABAAR, and this GABAergic activity may be involved in the neuroprotective effects against A -induced caspase 3/7 activation in rat primary neurons. Tramiprosate was also reported to be neuroprotective in rat neurons at least in part via inhibition of A 42-induced ERK1/2 activation by a GABAA-independent mechanism (see Fallon et al., poster presentation at this meeting). Together, these results demonstrate that the neuroprotective actions of tramiprosate involve at least two independent and potentially complementary mechanisms, one GABAergic and the other non-GABAergic.