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P‐184: APOE‐e4 carriers treated with statins have greater insulin‐mediated glucose disposal
Author(s) -
VanFossen Brian T.,
Watson G. Stennis,
Baker Laura D.,
Rhoads Kristoffer W.,
Cholerton Brenna A.,
Reger Mark A.,
Fishel Mark A.,
Plymate Steven R.,
Schellenberg Gerard D.,
Craft Suzanne
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.147
Subject(s) - apolipoprotein e , insulin , medicine , insulin resistance , endocrinology , atorvastatin , statin , dementia , diabetes mellitus , alzheimer's disease , disease
analysis demonstrated that age (odds ratio (OR) 1.079; 95% confidence interval (CI) 1.011-1.150), GDS 15 scores (OR 1.139; 95% CI 1.045-1.243), serum albumin (OR 0.336; 95% CI 0.174-0.745), and history of cerebrovascular disease (OR 3.011; 95% CI 1.578-5.748) were the variables significantly associated with having lower MMSE scores. Conclusion: Based on the results obtained in the current crosssectional assessment, the prevention of cerebrovascular disease may be a primary way of preventing cognitive decline in elderly DM subjects. An investigation of how lower serum albumin levels are associated with DM-related cognitive impairment may lead to the development of effective strategies for the prevention or treatment of this decline.