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P‐161: Amyloid beta (Aβ) is unaltered with highly elevated peripheral cholesterol in mice lacking the low‐density lipoprotein receptor
Author(s) -
Franciosi Sonia,
English Daniel,
Cho Julie,
Buxbaum Adina R.,
Schmidt Stephen D.,
Perez Gissel,
Mathews Paul M.,
De Gasperi Rita,
Sosa Miguel A. Gama,
Haroutunian Vahram,
Elder Gregory A.,
Buxbaum Joseph D.
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.124
Subject(s) - ldl receptor , cholesterol , medicine , apolipoprotein e , endocrinology , knockout mouse , apolipoprotein b , receptor , lipoprotein , chemistry , low density lipoprotein , biology , disease
satisfaction. The second study used new behavioral measures of self-regulation and estimation procedures based on occupational data (study in progress). Its aim was to study the differential effect of premorbid motivational and cognitive factors to the current cognitive and health status of older people. Results: Measures of motivational competence correlated significantly or highly significantly with satisfaction with life (r .30 .40). In a multiple regression analysis, motivation and decision regulation, self-efficacy and optimism showed to be most important to predict well-being in older age. Results of the second study will also be presented. Conclusions: We conclude suggesting adequate longitudinal studies to further investigate the concept of MR. The hypothesis is that premorbid motivational competence is associated with incidence and progression of Alzheimer’s dementia.