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O1–05–08: Memory decline in older adults is predicted by focused / selective attention
Author(s) -
Garcia Angeles,
Hemraj Alisha,
Klar Salman,
Lau Letty,
Thompson Kelly,
Chestney Tyler,
Day Andrew
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.075
Subject(s) - dementia , stroop effect , psychology , clinical dementia rating , receiver operating characteristic , california verbal learning test , cognition , cognitive decline , clinical psychology , audiology , verbal learning , medicine , psychiatry , cognitive impairment , disease
not available. MONDAY, JUNE 11, 2007 SYMPOSIUM S2-01 CLINICAL ISSUES S2-01-01 ROLE OF VASCULAR RISK FACTORS IN COGNITIVE DECLINE BEGINNING IN MIDDLE AGE David S. Knopman, Diane J. Catellier, Laura H. Coker, Thomas H. Mosley, Mayo Clinic, Rochester, MN, USA; University of North Carolina, Chapel Hill, NC, USA; Wake Forest University School of Medicine, Winston-Salem, NC, USA; University of Mississippi, Jackson, MS, USA. Contact e-mail: knopman@mayo.edu Background: By middle age, there are many vascular risk factors that might have an impact on cognition. Objective: To describe relationships of APOE genotype, stroke and vascular risk factors including diabetes, hypertension, hypercholesterolemia, cigarette smoking and others with cognitive change over a 14-year follow-up in the Atherosclerosis Risk in Communities (ARIC) Study cohort. Methods: The participants in the current study are a subset of the ARIC Study who underwent assessments of cognitive function and vascular risk factors. At baseline, the group was 59 4 yr of age, 62% female, 52% African American and 48% European American. Cognitive assessments were carried out at 4 time points between 1990 and 2006. The cognitive assessments included the Delayed Word Recall (DWR) test, the Digit Symbol Substitution (DSS) test and the Word Fluency (WF) test. Vascular risk factors were assessed at the baseline visit in 1990-1992. Both prevalent and incident strokes were used to create a time-dependent measure of stroke as a risk factor. Results: There were 1130 participants with longitudinal data. At baseline, there were already small, though statistically insignificant differences, in cognitive test scores depending on the presence or absence of risk factors. In the longitudinal data, in multivariate models adjusted for age, gender and race, diabetes and APOE e4 genotype were independently associated with decline in performance on the DSS test (both p .005), whereas hypertension and stroke were not. For DWR, stroke and APOE e4 genotype were independent predictors of decline (both p .001). For the WF test, hypertension and stroke were independently associated with decline (both p .005). In a separate model, metabolic syndrome was associated with decline in WF (p .001), but neither of the other cognitive tests. Conclusions: Diabetes, hypertension, APOE e4 genotype, metabolic syndrome and stroke were S179 Plenary: PL2: Early Detection and Diagnosis